3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 71093536, compound

HRID 927709Notes

Reaction equation

HRID 927709 reaction equation
[CH3:1][C:2]([NH:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15](Br)[N:14]=1)=[O:12])([C:4]1[N:8]=[C:7]([CH3:9])[O:6][N:5]=1)[CH3:3].[Cl:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][C:26]=1[F:27]>>[CH3:1][C:2]([NH:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:23]2[CH:24]=[CH:25][C:26]([F:27])=[C:21]([Cl:20])[CH:22]=2)[N:14]=1)=[O:12])([C:4]1[N:8]=[C:7]([CH3:9])[O:6][N:5]=1)[CH3:3]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 86674781HCID 86674781, compound

Product 1

HCID 71093536HCID 71093536, compound

Procedure

The title compound was synthesized in analogy to Example 267 b, 6-bromo-pyridine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide (Example 267a) and B-(3-chloro-4-fluorophenyl)-boronic acid (CAN 144432-85-9) as starting materials, LC-MS (UV peak area/ESI) 91%, 375.1018 (M+H)+.

Sources & evidence

ORD record
ord-3bde1e7e1639458e91d0ca5ec38c7bd6
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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