2-amino-2,4-dimethylpentan-1-ol → HCID 71114288, compound

HRID 927713Notes

Reaction equation

HRID 927713 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[NH2:21][C:22]([CH3:29])([CH2:25][CH:26]([CH3:28])[CH3:27])[CH2:23][OH:24]>>[OH:24][CH2:23][C:22]([NH:21][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH3:29])[CH2:25][CH:26]([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 220967012-amino-2,4-dimethylpentan-1-olHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 71114288HCID 71114288, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 2-amino-2,4-dimethylpentan-1-ol (CAN 13893-55-5) as starting materials. MS (EI): m/e=398.1 [M+H]+.

Sources & evidence

ORD record
ord-7a66af4ad93f4122b2ff575f72c540af
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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