Leucinamide → 6-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

HRID 927718Notes

Reaction equation

HRID 927718 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][C:7]2[N:12]=[C:11]([C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:18][C@@H:19]([CH2:23][CH:24]([CH3:26])[CH3:25])[C:20]([NH2:22])=[O:21]>>[C:20]([C@@H:19]([NH:18][C:13]([C:11]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=2)[N:12]=1)=[O:15])[CH2:23][CH:24]([CH3:26])[CH3:25])(=[O:21])[NH2:22]

Participants

3

Reactant 2

HCID 69640LeucinamideHCID 710874636-(4-Fluorobenzyl)picolinic acid

Product 1

HCID 711056856-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(4-fluorobenzyl)picolinic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials. MS (EI): m/e=344.0 [M+H]+.

Sources & evidence

ORD record
ord-bb99628090cf4b13aea10c8a30d6e8c3
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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