HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Fluorobenzyl)picolinic acid → 6-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Fluorobenzyl)picolinic acid | HCID 71087463 | — |
| Reactant | (R)-2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-amine hydrochloride | HCID 71087763 | — |
| Product | 6-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide | HCID 71105686 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 6-(4-fluorobenzyl)picolinic acid (Example 277 a) and (R)-2,2,2-trifluoro-1-(pyridin-2-yl)ethanamine hydrochloride (CAN 1228565-87-4) as starting materials. MS (EI): m/e=390.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290451B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-07ab728407044d56986a187827e2b4b0 |
| Source note | uspto-grants-2016_03 |