Sodium Hydroxide → 2-[(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid

HRID 927737Notes

Reaction equation

HRID 927737 reaction equation
C([O:3][C:4](=[O:29])[C:5]([NH:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[C:15]([O:24][CH2:25][CH:26]2[CH2:28][CH2:27]2)[N:14]=1)=[O:12])([CH2:8][CH3:9])[CH2:6][CH3:7])C.[OH-].[Na+]>>[CH:26]1([CH2:25][O:24][C:15]2[N:14]=[C:13]([C:11]([NH:10][C:5]([CH2:6][CH3:7])([CH2:8][CH3:9])[C:4]([OH:29])=[O:3])=[O:12])[CH:18]=[CH:17][C:16]=2[N:19]2[CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 710877682-[(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester

Product 1

HCID 710875502-[(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid

Procedure

In analogy to the procedure described in Example 252 b, 2-[(6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester (Example 289) was treated with sodium hydroxide to give the title compound as colorless oil. MS: 376.3 [M+H]+.

Sources & evidence

ORD record
ord-077ec954e4ee4411a34969a79654c87f
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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