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3,3-Difluoroazetidine → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3-Difluoroazetidine | HCID 2758248 | — |
| 反応物 | 2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-2-ethylbutanoic acid | HCID 71087739 | — |
| 生成物 | 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amide | HCID 71093579 | — |
反応手順
In analogy to the procedure described in Example 293, 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-2-ethylbutanoic acid and 3,3-difluoroazetidine (CAN 679431-52-8) were condensed to the title product. MS (EI): m/e=471.4 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290451B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-7032d083fddc45a98b5a34b18153ebc9 |
| 出典メモ | uspto-grants-2016_03 |