HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Leucine, ethyl ester, hydrochloride (1:1) → (S)-Ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Leucine, ethyl ester, hydrochloride (1:1) | HCID 11658447 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | (S)-Ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate | HCID 71105697 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid (Example 69 b) and (S)-ethyl 2-amino-4-methylpentanoate hydrochloride (CAN 2743-40-0) as starting materials. MS (EI): m/e=426.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290451B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-63b76ff91bf1432286e5b7ec6eb76021 |
| Source note | uspto-grants-2016_03 |