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HRID 927769作成日：2026年10月25日

3,3-Difluoroazetidine hydrochloride → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amide

https://huagongshe.com/reaction/927769

反応式

関与物質

役割名称HCID仕込み量
反応物3,3-Difluoroazetidine hydrochlorideHCID 2758247—
反応物2-(6-(Cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acidHCID 71087462—
生成物6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [1-(3,3-difluoro-azetidine-1-carbonyl)-1-ethyl-propyl]-amideHCID 71105699—

反応手順

In analogy to the procedure described in Example 293, 2-[(6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid (Example 252 b) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) were condensed to the title product. MS (EI): m/e=450.0 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290451B2
出典データセットuspto-grants-2016_03
ORD IDord-aa400665e1f74837b1bd925a4ba8c0d3
出典メモuspto-grants-2016_03