5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 71105713, compound

HRID 927784Notes

Reaction equation

HRID 927784 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C@@H:19]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)[C:20]([NH2:22])=[O:21]>>[C:20]([C@@H:19]([NH:18][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)(=[O:21])[NH2:22]

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 86674795HCID 86674795, compound

Product 1

HCID 71105713HCID 71105713, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (αS)-α-amino-4-chloro-benzeneacetamide (CAN 488836-04-0) as starting materials; LC-MS (UV peak area/ESI) 95%, 400.1434 (M+H)+.

Sources & evidence

ORD record
ord-8c2b89de1d4047a2b03f8713c8121a31
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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