Ethyl 2-amino-2-ethylbutanoate hydrochloride → Ethyl 2-(5-cyclopropyl-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamido)-2-ethylbutanoate
Reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH2:3][CH2:2]1.C1(C2C=CC(C(O)=O)=NC=2OCC2CCCO2)CC1.Cl.[NH2:41][C:42]([CH2:50][CH3:51])([CH2:48][CH3:49])[C:43]([O:45][CH2:46][CH3:47])=[O:44]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:41][C:42]([CH2:48][CH3:49])([CH2:50][CH3:51])[C:43]([O:45][CH2:46][CH3:47])=[O:44])=[O:20])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[CH2:2][CH2:3]1Participants
4
Reactant 3
Product 1
Procedure
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid (which can e.g. be prepared in a similar manner than 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b)) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=419.3 [M+H]+.
Sources & evidence
- ORD record
- ord-d305d977d23d45bab8e1a51fb9de0c3a
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290451B2
Reaction notes
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