Sodium Hydroxide → 2-{[5-Cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid

HRID 927796Notes

Reaction equation

HRID 927796 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:20][C:21]([CH2:29][CH3:30])([CH2:27][CH3:28])[C:22]([O:24]CC)=[O:23])=[O:19])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:20][C:21]([CH2:29][CH3:30])([CH2:27][CH3:28])[C:22]([OH:24])=[O:23])=[O:19])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 71087540Ethyl 2-(5-cyclopropyl-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamido)-2-ethylbutanoate

Product 1

HCID 710876592-{[5-Cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid

Procedure

In analogy to the procedure described in Example 252 b), ethyl 2-(5-cyclopropyl-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamido)-2-ethylbutanoate was treated with sodium hydroxide to give the title compound as white solid. MS: 389.3 [M−H]−.

Sources & evidence

ORD record
ord-fa65d16d32ff458da0da9b9b0527085a
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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