5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 71093652, compound

HRID 927799Notes

Reaction equation

HRID 927799 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([C:23]1[N:27]([CH3:28])[C:26](=[O:29])[O:25][N:24]=1)([CH3:22])[CH3:21]>>[CH3:22][C:20]([NH:19][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:23]1[N:27]([CH3:28])[C:26](=[O:29])[O:25][N:24]=1)[CH3:21]

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 86674797HCID 86674797, compound

Product 1

HCID 71093652HCID 71093652, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and 3-(1-amino-1-methyl-ethyl)-4-methyl-4H-[1,2,4]oxadiazol-5-one hydrochloride (1:1) (Example 338c) as starting materials; LC-MS (UV peak area/ESI) 99%, 373.1870 (M+H)+.

Sources & evidence

ORD record
ord-48951b12d0764ccc89ad45a9a98058aa
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

Loading…