(2S)-2-amino-4-(methylsulfanyl)butanamide hydrochloride → HCID 71087872, compound

HRID 927807Notes

Reaction equation

HRID 927807 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.Cl.[NH2:22][C@@H:23]([CH2:27][CH2:28][S:29][CH3:30])[C:24]([NH2:26])=[O:25]>>[C:24]([C@@H:23]([NH:22][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[CH2:27][CH2:28][S:29][CH3:30])(=[O:25])[NH2:26]

Participants

3

Reactant 2

HCID 18531008(2S)-2-amino-4-(methylsulfanyl)butanamide hydrochlorideHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 71087872HCID 71087872, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and (2S)-2-amino-4-(methylthio)-butanamide, monohydrochloride (CAN 14510-08-1) as starting materials. MS (EI): m/e=415.16 [M+H]+.

Sources & evidence

ORD record
ord-f32e1d4a4c904b609024c18bb9bd7921
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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