3-Amino-3-methyloxetane → HCID 71105753, compound

HRID 927835Notes

Reaction equation

HRID 927835 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[CH3:21][C:22]1([NH2:26])[CH2:25][O:24][CH2:23]1>>[CH3:21][C:22]1([NH:26][C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[CH2:18][C:17]([F:20])([F:19])[CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:25][O:24][CH2:23]1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 71105753HCID 71105753, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and (3-methyloxetan-3-yl)-amine (CAN 874473-14-0) as starting materials.

Sources & evidence

ORD record
ord-b2751898907040008dafe283a69977c6
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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