3-Amino-1,3-oxazinan-2-one → HCID 71105754, compound

HRID 927836Notes

Reaction equation

HRID 927836 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][N:19]1[CH2:24][CH2:23][CH2:22][O:21][C:20]1=[O:25]>>[O:25]=[C:20]1[N:19]([NH:18][C:15]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[CH2:24][CH2:23][CH2:22][O:21]1

Participants

3

Reactant 2

HCID 214274133-Amino-1,3-oxazinan-2-oneHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 71105754HCID 71105754, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and 3-aminotetrahydro-2H-1,3-oxazin-2-one (CAN 54924-47-9) as starting materials; LC-MS (UV peak area/ESI) 98.7%, 332.1612 (M+H)+.

Sources & evidence

ORD record
ord-6b1a4055a6044bdf936c6cebf82df254
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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