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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927850Generated: November 3, 2026

4-Hydroxybenzoic Acid → 2,4-Dihydroxybenzoic Acid

https://huagongshe.com/reaction/927850

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Hydroxybenzoic AcidHCID 135—
ReactantMethanolHCID 887—
ReactantTetrahydrofuranHCID 8028—
Product2,4-Dihydroxybenzoic AcidHCID 1491—
Product2,5-Dihydroxybenzoic acidHCID 3469—
Product3-Hydroxybenzoic AcidHCID 7420—

Reaction Steps

Crystallization processes performed with hydroxybenzoic acids gave different results, for example for crystallization of saturated solutions of 4-hydroxybenzoic acid in methanol resulted in a new phase, as shown in FIG. 1. Similarly using methanol or THF, NSF were obtained with the co-formers 3-hydroxybenzoic acid (FIG. 10), 2,4-dihydroxybenzoic acid (FIG. 11), 2,5-dihydroxybenzoic acid (FIGS. 6A, 6B and 6C), 3,4-hydroxybenzoic acid (FIGS. 12A and 12B) and 3,5-hydroxybenzoic acid (FIG. 13).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290492B2
Source datasetuspto-grants-2016_03
ORD IDord-9dbe10e06db448b8a50a0b69ef73bb04
Source noteuspto-grants-2016_03