4-Dimethylaminobutylamine → (1aRS,7bSR)-5-[2-(4-Dimethylaminobutylamino)benzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

HRID 927859Notes

Reaction equation

HRID 927859 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:21]([C:22]([OH:24])=[O:23])=[C:20]2[C:15]([CH:16]3[CH2:25][CH:17]3[CH2:18][O:19]2)=[CH:14][CH:13]=1)(=[O:10])=[O:9].[CH3:26][N:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31][NH2:32]>>[CH3:26][N:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:21]([C:22]([OH:24])=[O:23])=[C:20]2[C:15]([CH:16]3[CH2:25][CH:17]3[CH2:18][O:19]2)=[CH:14][CH:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 770634-DimethylaminobutylamineHCID 86713249(1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid2×

Product 1

HCID 71006861(1aRS,7bSR)-5-[2-(4-Dimethylaminobutylamino)benzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Procedure

Prepared by proceeding in a similar manner to Example 26, starting from (1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid (Intermediate 67) and 4-dimethylaminobutylamine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dc1c49d470a1403f9e3352fe7de47a5b
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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