HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927912Generated: November 4, 2026
methyl 7-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxy-carbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate → Methyl 7-[N-{2-((Z)-3-Diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate
https://huagongshe.com/reaction/927912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | methyl 7-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxy-carbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate | HCID 71006926 | — |
| Reactant | Methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylate | HCID 86684725 | — |
| Reactant | N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)amine | HCID 86684726 | — |
| Product | Methyl 7-[N-{2-((Z)-3-Diethylaminoprop-1-enyl)-4-fluoro-benzenesulfonyl}-N-(methoxycarbonyl)amino]-1,2-dihydrofuro[2,3-c]quinoline-6-carboxylate | HCID 86713282 | — |
Reaction Steps
Prepared by proceeding in a similar manner to Intermediate 9, starting from methyl 7-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxycarbonyl)amino]-1,2-dihydro-furo[2,3-c]quinoline-6-carboxylate (Intermediate 21) and N,N-diethyl-N—((Z)-1-tributylstannanylprop-1-en-3-yl)amine (Intermediate 11) and heating at 60° C. for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09290472B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-26fad2181d40484ba2d4e3109b2ab721 |
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| Source note | uspto-grants-2016_03 |
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