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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927941Generated: November 3, 2026

1-Bromo-2-butyne → Methyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-(but-2-ynyloxy)benzoate

https://huagongshe.com/reaction/927941

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-butyneHCID 2756862—
ReactantMethyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-hydroxybenzoateHCID 71006903—
ReactantMethyl 2-(2,2-dimethylpropionylamino)-6-(prop-2-ynyloxy)benzoateHCID 86713295—
ProductMethyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-(but-2-ynyloxy)benzoateHCID 90086596—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 46, starting from methyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-hydroxybenzoate (Intermediate 55) and 1-bromobut-2-yne

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290472B2
Source datasetuspto-grants-2016_03
ORD IDord-f7338b1ac84349d0a4728c36a313430f
Source noteuspto-grants-2016_03