HRID927946

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCN(CC)C/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)OCc1occc1-2$

HCID86684725

未命名化合物

$结构：CCC[CH2][Sn](/[CH]=C\CN(CC)CC)([CH2]CCC)[CH2]CCC$

HCID86684726

未命名化合物

2 次

结构：COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1OCC1C2C1(F)F

HCID86713302

未命名化合物

2 次

PRODUCTS

生成物

$结构：CCN(CC)C/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)OCC1C2C1(F)F$

HCID86713301

未命名化合物

PROCEDURE

实验过程

Prepared by proceeding in a similar manner to Intermediate 9, starting from methyl (1aRS,7bSR)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1-difluoro-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-4-carboxylate (Intermediate 60) and N,N-diethyl-N—((Z)-1-tributylstannanylprop-1-en-3-yl)amine (Intermediate 11) as a pale yellow gum.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-946f51be83dd420b8dbb243c11fec2d9
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290472B2
来源说明: uspto-grants-2016_03

反应 SMILES

[CH2:1]([N:3]([CH2:35][CH3:36])[CH2:4]/[CH:5]=[CH:6]\C1C=C(F)C=CC=1S(NC1C(C(OC)=O)=C2C(C3C=COC=3CO2)=CC=1)(=O)=O)[CH3:2].Br[C:38]1[CH:43]=[C:42]([F:44])[CH:41]=[CH:40][C:39]=1[S:45]([NH:48][C:49]1[C:58]([C:59]([O:61][CH3:62])=[O:60])=[C:57]2[C:52]([CH:53]3[C:63]([F:65])([F:64])[CH:54]3[CH2:55][O:56]2)=[CH:51][CH:50]=1)(=[O:47])=[O:46].C(N(CC)C/C=C\[Sn](CCCC)(CCCC)CCCC)C>>[CH2:1]([N:3]([CH2:35][CH3:36])[CH2:4]/[CH:5]=[CH:6]\[C:38]1[CH:43]=[C:42]([F:44])[CH:41]=[CH:40][C:39]=1[S:45]([NH:48][C:49]1[C:58]([C:59]([O:61][CH3:62])=[O:60])=[C:57]2[C:52]([CH:53]3[C:63]([F:65])([F:64])[CH:54]3[CH2:55][O:56]2)=[CH:51][CH:50]=1)(=[O:47])=[O:46])[CH3:2]