2-Bromo-4-fluorobenzene-1-sulfonyl chloride → Methyl (1aRS,7bSR)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1-difluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-4-fluorobenzene-1-sulfonyl chloride	HCID 2778216	—
Reactant	methyl cis-(3aRS,9bRS)-7-(2-bromo-4-fluorobenzenesulfonylamino)-1,3a,4,9b-tetrahydro-2H-furo[2,3-c]chromene-6-carboxylate	HCID 86713280	—
Reactant	Methyl (1aRS,7bSR)-5-amino-1,1-difluoro-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate	HCID 86713303	—
Product	Methyl (1aRS,7bSR)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1-difluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate	HCID 86713302	—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 18, starting from methyl (1aRS,7bSR)-5-amino-1,1-difluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate (Intermediate 61) and 2-bromo-4-fluorobenzene sulfonyl chloride, as a colourless foam.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09290472B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-c261dd53226142c3a27b41b0d03e7780
Source note	uspto-grants-2016_03