HRID927959

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2Br)ccc2c1OCC1CC21

HCID77979724

未命名化合物

2 次

$结构：COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2/C=C\CO)ccc2c1OCC1CC21$

HCID86713304

未命名化合物

PRODUCTS

生成物

$结构：COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2/C=C\CCO)ccc2c1OCC1CC21$

HCID86713307

未命名化合物

PROCEDURE

实验过程

Prepared by proceeding in a similar manner to Intermediate 64, starting from methyl (1aRS,7bSR)-5-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxycarbonyl)amino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate (Intermediate 65) and (Z)-4-tributylstannanylprop-3-en-1-ol (prepared according to Miura et al, Organic Letters, 2005, 7(3) 503).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5c4a1935611640438e189054178385de
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290472B2
来源说明: uspto-grants-2016_03

反应 SMILES

[CH3:1][O:2][C:3]([N:5]([C:20]1[C:29]([C:30]([O:32][CH3:33])=[O:31])=[C:28]2[C:23]([CH:24]3[CH2:34][CH:25]3[CH2:26][O:27]2)=[CH:22][CH:21]=1)[S:6]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1/[CH:16]=[CH:17]\[CH2:18]O)(=[O:8])=[O:7])=[O:4].BrC1C=C(F)C=CC=1S(N(C1C(C(OC)=O)=C2C(C3CC3CO2)=CC=1)[C:47](OC)=[O:48])(=O)=O>>[CH3:1][O:2][C:3]([N:5]([C:20]1[C:29]([C:30]([O:32][CH3:33])=[O:31])=[C:28]2[C:23]([CH:24]3[CH2:34][CH:25]3[CH2:26][O:27]2)=[CH:22][CH:21]=1)[S:6]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1/[CH:16]=[CH:17]\[CH2:18][CH2:47][OH:48])(=[O:7])=[O:8])=[O:4]