HRID927963

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1514290

Azetidin-3-ol

C3H7NO

$结构：CCNC/C=C\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)OCC1CC21$

HCID86713248

未命名化合物

$结构：COC(=O)c1c(N(C(=O)OC)S(=O)(=O)c2ccc(F)cc2/C=C\CO)ccc2c1OCC1CC21$

HCID86713304

未命名化合物

2 次

PRODUCTS

生成物

$结构：COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2/C=C\CN2CC(O)C2)ccc2c1OCC1CC21$

HCID86713310

未命名化合物

PROCEDURE

实验过程

Prepared by proceeding in a similar manner to Intermediate 63, starting from methyl (1aRS,7bSR)-5-{N-[methoxycarbonyl]-N-[2-((Z)-3-hydroxyprop-1-enyl)-4-fluorobenzene-sulfonyl]amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate (Intermediate 64) and 3-hydroxyazetidine as a yellow oil.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9e49dd4eb4141deb2f3e57f44dbaac4
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290472B2
来源说明: uspto-grants-2016_03

反应 SMILES

C(NC/C=C\C1C=C(F)C=CC=1S(NC1C(C(OC)=O)=C2C(C3CC3CO2)=CC=1)(=O)=O)C.COC([N:37]([C:52]1[C:61]([C:62]([O:64][CH3:65])=[O:63])=[C:60]2[C:55]([CH:56]3[CH2:66][CH:57]3[CH2:58][O:59]2)=[CH:54][CH:53]=1)[S:38]([C:41]1[CH:46]=[CH:45][C:44]([F:47])=[CH:43][C:42]=1/[CH:48]=[CH:49]\[CH2:50]O)(=[O:40])=[O:39])=O.[OH:67][CH:68]1[CH2:71][NH:70][CH2:69]1>>[OH:67][CH:68]1[CH2:71][N:70]([CH2:50]/[CH:49]=[CH:48]\[C:42]2[CH:43]=[C:44]([F:47])[CH:45]=[CH:46][C:41]=2[S:38]([NH:37][C:52]2[C:61]([C:62]([O:64][CH3:65])=[O:63])=[C:60]3[C:55]([CH:56]4[CH2:66][CH:57]4[CH2:58][O:59]3)=[CH:54][CH:53]=2)(=[O:39])=[O:40])[CH2:69]1