(R)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine → (S)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine

HRID 927995Notes

Reaction equation

HRID 927995 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=2)[CH2:4]1)[CH3:2].FC1C=C(C=CC=1)C[C@H]1CCNC1>>[CH2:1]([N:3]1[CH2:7][CH2:6][C@H:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=2)[CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 70983712(R)-1-ethyl-3-(3-fluorobenzyl)pyrrolidineHCID 863184953-(S)-(3-Fluorobenzyl)-pyrrolidine2×

Product 1

HCID 70984055(S)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine

Procedure

Prepared by proceeding in a similar manner to Intermediate 97 starting with 3-(S)-(3-fluoro-benzyl)pyrrolidine (Intermediate 116).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c851e24399cb4debbbe36ea179b849d9
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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