tert-butyl (S)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate → 3-(S)-(3-Fluorobenzyl)-pyrrolidine

HRID 927996Notes

Reaction equation

HRID 927996 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][C@@H:6]1[CH2:10][CH2:9][NH:8][CH2:7]1.FC1C=C(C=CC=1)C[C@H]1CCN(C(OC(C)(C)C)=O)C1>>[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][C@H:6]1[CH2:10][CH2:9][NH:8][CH2:7]1

Participants

3

Reactant 2

HCID 71006981tert-butyl (S)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate2×HCID 863184933-(R)-(3-fluorobenzyl)pyrrolidine

Product 1

HCID 863184953-(S)-(3-Fluorobenzyl)-pyrrolidine

Procedure

Prepared by proceeding in a similar manner to Intermediate 98 starting with tert-butyl (S)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate (intermediate 117).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-911a2e5c12ff4e7ca100afba92cb2103
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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