methyl (1aRS,7bSR)-5-(2-carboxymethyl-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate → Methyl (1aRS,7bSR)-5-(2-{[N-((R)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	methyl (1aRS,7bSR)-5-(2-carboxymethyl-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate	HCID 71006995	—
Reactant	methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methylcarbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate	HCID 86713257	—
Reactant	N-((R)-1-ethylpyrrolidin-3-yl)-N-methylamine dihydrochloride	HCID 86713336	—
Product	Methyl (1aRS,7bSR)-5-(2-{[N-((R)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate	HCID 86713335	—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 126, starting from methyl (1aRS,7bSR)-5-(2-carboxymethyl-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-4-carboxylate (Intermediate 83) and N—((R)-1-ethylpyrrolidin-3-yl)-N-methylamine dihydrochloride (Intermediate 132) as a light brown foam.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09290472B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-ec78972054bf4d7b88c27fcdaa716a33
Source note	uspto-grants-2016_03