Methyl iodide → HCID 59850229, compound

HRID 928010Notes

Reaction equation

HRID 928010 reaction equation
[CH2:1]([O:8][C:9]([N:11]([C@H:13]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14]1)[CH3:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(N[C@@H]1CCN(C(OC(C)(C)C)=O)C1)=O)C1C=CC=CC=1.IC>>[CH2:1]([O:8][C:9]([N:11]([C@@H:13]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14]1)[CH3:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 115370521,1-Dimethylethyl (3R)-3-[[(phenylmethoxy)carbonyl]amino]-1-pyrrolidinecarboxylateHCID 86713334HCID 86713334, compound

Product 1

HCID 59850229HCID 59850229, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 130, starting from tert-butyl (R)-3-benzyloxycarbonylaminopyrrolidine-1-carboxylate (prepared according to Zhou et al, US 2008 0293771) and iodomethane, as a pale coloured oil.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1665c0cc61354a109689706670934011
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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