(S)-2-(1-Acetylpyrrolidin-2-yl)acetonitrile → ((R)-1-Acetylpyrrolidin-2-yl)acetonitrile

HRID 928017Notes

Reaction equation

HRID 928017 reaction equation
[C:1]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[CH2:9][C:10]#[N:11])(=[O:3])[CH3:2].Cl.N1CCC[C@@H]1CC#N>>[C:1]([N:4]1[CH2:8][CH2:7][CH2:6][C@@H:5]1[CH2:9][C:10]#[N:11])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 45085914(S)-2-(1-Acetylpyrrolidin-2-yl)acetonitrileHCID 86713341(R)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride2×

Product 1

HCID 86713340((R)-1-Acetylpyrrolidin-2-yl)acetonitrile

Procedure

Prepared by proceeding in a similar manner to Intermediate 137, starting from ((R)-pyrrolidin-2-yl)acetonitrile hydrochloride (Intermediate 143) and used without further characterisation.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1b66844c26954c2fa1493584483f9074
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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