1-ethyl-L-Proline → (2R)-1-ethylpyrrolidine-2-carboxylic acid

HRID 928022Notes

Reaction equation

HRID 928022 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([OH:10])=[O:9])[CH3:2].C(N1CCC[C@@H]1C(OC(C)(C)C)=O)C>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[C:8]([OH:10])=[O:9])[CH3:2]

Participants

3

Reactant 2

HCID 283547181-ethyl-L-ProlineHCID 80709654tert-butyl (R)-1-ethylpyrrolidine-2-carboxylate2×

Product 1

HCID 28354716(2R)-1-ethylpyrrolidine-2-carboxylic acid

Procedure

Prepared by proceeding in a similar manner to Intermediate 106, starting from tert-butyl (R)-1-ethylpyrrolidine-2-carboxylate (Intermediate 148) as a solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-136c981539c64c64bb6a51caf598ea63
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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