benzyl (2R)-pyrrolidine-2-carboxylate → Benzyl (R)-1-ethylpyrrolidine-2-carboxylate

HRID 928023Notes

Reaction equation

HRID 928023 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[CH3:2].N1CCC[C@@H]1C(OCC1C=CC=CC=1)=O>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])[CH3:2]

Participants

3

Reactant 2

HCID 736154benzyl (2R)-pyrrolidine-2-carboxylateHCID 10421496benzyl (S)-N-ethylpyrrolidine-2-carboxylate

Product 1

HCID 71006989Benzyl (R)-1-ethylpyrrolidine-2-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 107, starting from benzyl (R)-pyrrolidine-2-carboxylate as a colourless oil.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b4f2374032904434b80166e8a2117dde
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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