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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 928074Generated: October 29, 2026

tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate → tert-butyl (R)-3-(2-bromo-5-fluorobenzyloxy)pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/928074

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylateHCID 6544479—
Reactanttert-butyl (S)-3-(2-bromo-5-fluorobenzyloxy)pyrrolidine-1-carboxylateHCID 68923111—
Producttert-butyl (R)-3-(2-bromo-5-fluorobenzyloxy)pyrrolidine-1-carboxylateHCID 86713373—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 216, starting from tert-butyl(R)-3-hydroxy-pyrrolidine-1-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290472B2
Source datasetuspto-grants-2016_03
ORD IDord-1734addc93844d95aab9c7b52a005c1f
Source noteuspto-grants-2016_03