Diisopropylethylamine → 2-fluoro-9-isopropyl-N-(1-methyl-1H-pyrazol-4-yl)-9H-purin-6-amine

Participants

Reaction Steps

A mixture of 6-chloro-2-fluoro-9-isopropyl-9H-purine (215 mg, 1 mmol), 1-methyl-1H-pyrazol-4-amine (116 mg, 1.2 mmol) in nBuOH (5 mL, 0.2 M) and DIPEA (0.7 mL, 4 mmol) was stirred at ambient temperature for 2 days. LCMS showed major title product with M+1=276.2 amu. This crude product was used in the following step with no isolation.

Provenance & Evidence