Water → benzyl (3R,4R)-3-amino-4-fluoropyrrolidine-1-carboxylate

To a stirred solution of (trans)-benzyl 3-azido-4-fluoropyrrolidine-1-carboxylate (30 g, 0.114 mol) in THF (0.3 L) was added PPh3 (33 g, 0.126 mol) portion wise at 0-5° C. The resulting mixture was then warmed to rt and stirred for 2 hr. 30 mL of water was then added and the resulting mixture was heated to reflux overnight. The reaction mixture was concentrated and the residue diluted with EtOAc (0.2 L) and extracted with sat. citric acid (4×100 mL). The combined aqueous extracts were washed with EtOAc (3×50 mL), then adjusted pH to 8 with sat. aq. K2CO3, and extracted with DCM (4×100 mL). The combined organic extracts were washed with brine (100 mL), dried over Na2SO4, concentrated, then dried in vacuo to give the title compound as light yellow oil that solidified on standing to afford an off-white solid (16 g, 59% yield).

1. temperaturethe resulting mixture was heated
2. temperatureto reflux overnight
3. concentrationThe reaction mixture was concentrated
4. additionthe residue diluted with EtOAc (0.2 L)
5. extractionextracted with sat. citric acid (4×100 mL)
6. washThe combined aqueous extracts were washed with EtOAc (3×50 mL)
7. extractionextracted with DCM (4×100 mL)
8. washThe combined organic extracts were washed with brine (100 mL)
9. dry with materialdried over Na2SO4
10. concentrationconcentrated
11. customdried in vacuo

ORD record

ord-65c69b2219ed4c899863f0410ec0db27

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09290496B2