Aluminium lithium hydride → HCID 86679680, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (+/−)-cis-5-benzyl-3a-methoxytetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (4.5 g, 17 mmol) in THF (200 mL) was added LAH solution (35 mL, 35 mmol, 1 M in THF) at 0° C. The resulting mixture was stirred at 45° C. overnight. TLC (petroleum ether/EtOAc=1/1) showed the reaction was complete. The mixture was quenched by water (3 mL) and filtered. The filtrate was concentrated to afford crude title compound (3.7 g, crude), which was used for the next step directly.

Provenance & Evidence