HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one | HCID 136109958 | — |
| Product | 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one | HCID 136109957 | — |
Reaction Steps
A solution of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 in pyrrolidine was heated in a microwave cavity (Power=270 W, Temp=110° C.) for 12 min. The pyrrolidine was evaporated, then residue partitioned between NaHCO3 0.5 N and CH2Cl2, dried (Na2SO4) and evaporated. Trituration in Et2O afforded the title product 110 as a yellow powder (LCMS analysis).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290502B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bcd291c8f63c4093805a96ab93d1a512 |
| Source note | uspto-grants-2016_03 |