O-Toluidine → 2-(5-Bromo-2-fluorophenyl)-4-(2-tolylamino)pteridine

HRID 928278Notes

Reaction equation

HRID 928278 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[CH3:20][C:21]1[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=1[NH2:23].C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[N:17]=[C:16]([NH:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH3:20])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 7242O-ToluidineHCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

Product 1

HCID 444320642-(5-Bromo-2-fluorophenyl)-4-(2-tolylamino)pteridine

Procedure

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 2-methylaniline following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

Sources & evidence

ORD record
ord-b7ccb91655c548d19189dd7e74c32322
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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