Ethanolamine → HCID 57742377, compound

HRID 928281Notes

Reaction equation

HRID 928281 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[OH:20][CH2:21][CH2:22][NH2:23].C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[N:17]=[C:16]([NH:23][CH2:22][CH2:21][OH:20])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

Product 1

HCID 57742377HCID 57742377, compound

Procedure

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 2-hydroxyethylamine following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

Sources & evidence

ORD record
ord-c49ddb7a10c94b1ab965a25649134045
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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