4-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine → HCID 57742376, compound

HRID 928284Notes

Reaction equation

HRID 928284 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[N:20]1([CH2:25][CH2:26][NH:27][C:28]2[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1.C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[N:17]=[C:16]([N:27]([CH2:26][CH2:25][N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 58970204HCID 58970204, compoundHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

Product 1

HCID 57742376HCID 57742376, compound

Procedure

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 4-[2-(pyrrolidin-1-yl)ethylamino]pyridine following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)-pteridine 3.

Sources & evidence

ORD record
ord-5526fabbd7484929bb6d91a696ea7fe5
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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