3-Methyl-4-pyridinamine → 2-(5-Chloro-2-fluorophenyl)-4-(3-methyl-4-pyridylamino)pteridine

HRID 928289Notes

Reaction equation

HRID 928289 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[NH2:20][C:21]1[CH:26]=[CH:25][N:24]=[CH:23][C:22]=1[CH3:27].C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[N:17]=[C:16]([NH:20][C:21]3[CH:26]=[CH:25][N:24]=[CH:23][C:22]=3[CH3:27])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 748113-Methyl-4-pyridinamineHCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 1357412962-(5-Chloro-2-fluorophenyl)pteridin-4(3H)-one

Product 1

HCID 444320552-(5-Chloro-2-fluorophenyl)-4-(3-methyl-4-pyridylamino)pteridine

Procedure

The title product was synthesized by reaction of the 2-(5-chloro-2-fluorophenyl)-pteridin-4-one with 4-amino-3-methylpyridine following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

Sources & evidence

ORD record
ord-cdccc2629fdc4b3e891ebe711085e4d0
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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