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HRID 928300作成日：2026年10月25日

2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) → (S,E)-4-(8-Amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

https://huagongshe.com/reaction/928300

反応式

関与物質

役割名称HCID仕込み量
反応物2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)HCID 14805664—
反応物(S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamideHCID 71226368—
生成物(S,E)-4-(8-Amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamideHCID 7122638546.6%

反応手順

This compound was prepared, in an analogous manner as described in Example 2, from the compound described in intermediate 2b and (E)-4-(dimethylamino)but-2-enoic acid, to afford the title compound (11.8 mg, 46.6%). Data: UPLC (C) Rt: 1.29 min; m/z 511.0 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290504B2
出典データセットuspto-grants-2016_03
ORD IDord-3b92e5ecd9f94c1092a334c31c50b4b4
出典メモuspto-grants-2016_03