HRID928305

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OB(c2ccc(C(=O)Nc3cc(F)ccn3)cc2)OC1(C)C

HCID71222688

未命名化合物

2 次

结构：Nc1nccn2c([C@@H]3CCCN3)nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c12

HCID71226368

未命名化合物

结构：Nc1nccn2c([C@@H]3CCCN3C(=O)OCc3ccccc3)nc(Br)c12

HCID71233875

1-Pyrrolidinecarboxylic acid, 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-, phenylmethyl ester, (2S)-

C18H18BrN5O2

2 次

PRODUCTS

生成物

结构：Nc1nccn2c([C@@H]3CCCN3)nc(-c3ccc(C(=O)Nc4cc(F)ccn4)cc3)c12

HCID86720305

未命名化合物

收率 93%

PROCEDURE

实验过程

This intermediate was prepared, in an analogous manner as described for intermediate 2b, from (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate (Intermediate 1e) and N-(4-fluoropyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (intermediate 4b) to afford the title compound (331 mg, 93%).

WORKUP

后处理

customThis intermediate was prepared, in an analogous manner