4-Propylpyridin-2-amine → N-(4-propylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

HRID 928309Notes

Reaction equation

HRID 928309 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9](=[O:25])[C:10]2[CH:15]=[CH:14][C:13]([B:16]3[O:20][C:19]([CH3:22])([CH3:21])[C:18]([CH3:24])([CH3:23])[O:17]3)=[CH:12][CH:11]=2)[CH:3]=1.[CH2:26](C1C=CN=C(N)C=1)[CH2:27]C>>[CH2:1]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9](=[O:25])[C:10]2[CH:11]=[CH:12][C:13]([B:16]3[O:20][C:19]([CH3:21])([CH3:22])[C:18]([CH3:24])([CH3:23])[O:17]3)=[CH:14][CH:15]=2)[CH:3]=1)[CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 70225944-Propylpyridin-2-amineHCID 17999246N-(4-Methylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Product 1

HCID 71222857N-(4-propylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamideYield 54.1%

Procedure

This compound was prepared, in an analogous manner as described in Intermediate 6, starting from 4-propylpyridin-2-amine, to afford the title compound (371.5 mg, 54.1%).

Workup

  1. customThis compound was prepared, in an analogous manner

Sources & evidence

ORD record
ord-26cba72d1a934806b2feb068f6e088b1
Source dataset
uspto-grants-2016_03
Patent number
US09290504B2

Reaction notes

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