HRID928311

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15302979

未命名化合物

2 次

结构：CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4)n4ccnc(N)c34)cc2)c1

HCID71226711

未命名化合物

2 次

PRODUCTS

生成物

结构：CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4C(=O)/C=C/COC)n4ccnc(N)c34)cc2)c1

HCID71226728

未命名化合物

收率 65.7%

PROCEDURE

实验过程

This compound was prepared, in an analogous manner as described in Example 2, from (S)-4-(8-amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-propylpyridin-2-yl)benzamide (intermediate 9) and (E)-4-methoxybut-2-enoic acid (Intermediate 3), to afford the title compound (30.9 mg, 65.7%). Data: UPLC (C) R: 2.73 min; m/z 566.3 (M+H)+.

WORKUP

后处理

customThis compound was prepared, in an analogous manner

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4cbb38d902264e20b236d9b192b8f9ae
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290504B2
来源说明: uspto-grants-2016_03

反应 SMILES

[NH2:1][C:2]1[C:3]2[N:4]([C:8]([C@@H:29]3[CH2:33][CH2:32][CH2:31][NH:30]3)=[N:9][C:10]=2[C:11]2[CH:28]=[CH:27][C:14]([C:15]([NH:17][C:18]3[CH:23]=[C:22]([CH2:24][CH2:25][CH3:26])[CH:21]=[CH:20][N:19]=3)=[O:16])=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1.[CH3:34][O:35][CH2:36]/[CH:37]=[CH:38]/[C:39](O)=[O:40]>>[NH2:1][C:2]1[C:3]2[N:4]([C:8]([C@@H:29]3[CH2:33][CH2:32][CH2:31][N:30]3[C:39](=[O:40])/[CH:38]=[CH:37]/[CH2:36][O:35][CH3:34])=[N:9][C:10]=2[C:11]2[CH:12]=[CH:13][C:14]([C:15]([NH:17][C:18]3[CH:23]=[C:22]([CH2:24][CH2:25][CH3:26])[CH:21]=[CH:20][N:19]=3)=[O:16])=[CH:27][CH:28]=2)[CH:5]=[CH:6][N:7]=1