2-Amino-4-(trifluoromethyl)pyridine → 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-4-(trifluoromethyl)pyridine	HCID 2778315	—
Reactant	N-(4-Methylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide	HCID 17999246	—
Product	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide	HCID 71222797	89%

Reaction Steps

This compound was prepared, in an analogous manner as described in Intermediate 6, starting from 4-(trifluoromethyl)pyridin-2-amine, to afford the title compound (657.2 mg, 89%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09290504B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-ee775935f41d47a7ba446319b103983b
Source note	uspto-grants-2016_03