HRID928315

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1ccnc(NC(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1

HCID71222661

未命名化合物

2 次

结构：Nc1nccn2c([C@@H]3CCCN3C(=O)OCc3ccccc3)nc(Br)c12

HCID71233875

1-Pyrrolidinecarboxylic acid, 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-, phenylmethyl ester, (2S)-

C18H18BrN5O2

2 次

PRODUCTS

生成物

结构：CCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4)n4ccnc(N)c34)cc2)c1

HCID71225845

未命名化合物

收率 89%

PROCEDURE

实验过程

This intermediate was prepared, in an analogous manner as described for intermediate 2, from (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate (Intermediate 1e) and N-(4-ethylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (intermediate 12) to afford the title compound (133.8 mg, 89%).

WORKUP

后处理

customThis intermediate was prepared, in an analogous manner