HRID928324

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44118748

{4-[(1,3-Thiazol-2-yl)carbamoyl]phenyl}boronic acid

C10H9BN2O3S

结构：Nc1nccn2c([C@@H]3CCCN3C(=O)OCc3ccccc3)nc(Br)c12

HCID71233875

1-Pyrrolidinecarboxylic acid, 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-, phenylmethyl ester, (2S)-

C18H18BrN5O2

2 次

PRODUCTS

生成物

结构：Nc1nccn2c([C@@H]3CCCN3)nc(-c3ccc(C(=O)Nc4nccs4)cc3)c12

HCID86720312

未命名化合物

收率 73.1%

PROCEDURE

实验过程

This intermediate was prepared, in an analogous manner as described for intermediate 2, from (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate (Intermediate 1e) and commercially available N-2-thiazolyl 4-boronobenzamide to afford the title compound (229 mg, 73.1%).

WORKUP

后处理

customThis intermediate was prepared, in an analogous manner