HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxysuccinimide S-acetylthioacetate → (S)-S-2-(2-(8-Amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-2-oxoethyl ethanethioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxysuccinimide S-acetylthioacetate | HCID 127532 | — |
| Reactant | (S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide | HCID 71226368 | — |
| Product | (S)-S-2-(2-(8-Amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-2-oxoethyl ethanethioate | HCID 86720322 | 31.8% |
Reaction Steps
This compound was prepared, in an analogous manner as described in Example 1, from the compound described in intermediate 2b and 2,5-dioxopyrrolidin-1-yl 2-(acetylthio)acetate, to afford the title compound (12.3 mg, 31.8%). Data: UPLC (C) R: 1.51 min; m/z 516.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290504B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bb823ed57013428c84233add4cbfec05 |
| Source note | uspto-grants-2016_03 |