HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 928366Generated: October 29, 2026
Diisopropylethylamine → 1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-imidazole-4-carboxylic acid methyl ester
https://huagongshe.com/reaction/928366
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 3-(dimethylamino)-2-isocyanoacrylate | HCID 2758506 | — |
| Reactant | {4-[(1H-pyrazol-1-yl)methyl]phenyl}methanamine | HCID 7131579 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-imidazole-4-carboxylic acid methyl ester | HCID 58081308 | — |
Reaction Steps
A mixture of 4-Pyrazol-1-ylmethyl-benzylamine (550 mg, 2.5 mmol), (Z)-methyl-3-(dimethylamino)-2-isocyanoacrylate (380 mg, 2.5 mmol) and DIPEA (1.3 mL, 7.4 mmol) in 20 mL nBuOH was heated to 120° C. for 16 h. The mixture was concentrated in vacuo and the crude product was used in the next step without further purification. LCMS (method A) RtA=1.210 min; [M+H]+=297.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09290485B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-5b508a04cd734dd5b83b63da1e94f590 |
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| Source note | uspto-grants-2016_03 |
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