Hexane → HCID 58081245, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-((1H-pyrazol-1-yl)methyl)-3-methoxybenzoate (330 mg crude) in THF (6 ml) DIBAL-H 1M in Hexane (4.02 ml, 4.02 mmol) was added dropwise at −70° C. The reaction mixture was stirred at −70° C. for 3.5 h. The reaction mixture was quenched subsequently with ethyl acetate (2 ml) and saturated aqueous NH4Cl. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to afford crude (4-((1H-pyrazol-1-yl)methyl)-3-methoxyphenyl)methanol. MS [M+H]+=219.

Provenance & Evidence