HCID 58081337, compound → HCID 58081240, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of crude ethyl 1-(4-((1H-pyrazol-1-yl)methyl)-3-methoxybenzyl)-1H-pyrazole-4-carboxylate (998 mg, 29%, 0.85 mmol) in THF:EtOH:H2O 2:1:1 (15 ml), LiOH Monohydrate (107 mg, 2.55 mmol) was added and stirred for 12 h at 50° C. The reaction mixture was concentrated under reduced pressure. The remaining solid was taken up in ethyl acetate and extracted with water. The aqueous phase was acidified by adding aqueous HCl and extracted with ethy acetate. The organic extract was dried over Na2SO4, filtered and concentrated under reduced pressure to afford crude 1-(4-((1H-pyrazol-1-yl)methyl)-3-methoxybenzyl)-1H-pyrazole-4-carboxylic acid. MS [M+H]+=313.

Provenance & Evidence